Month: April 2019

The Soul

Experiencing the Soul

Our experience of seeing, remembering and visualizing all hinge on the ability of the mind to place our awareness at the center of a spherical reality that converts incoming sensory information from our  nervous system, particularly eyes, memory and imagination into a manipulable visual construct.

The visual aspect of our being is a only a part of total sensory input, but pivotal to understanding how we survive death and return again and again to complete our goals for living. We call it the soul, and it has two important qualities that seem very different during analysis. First there is the ability to contain the experience of living and review it, whether it is a moment later or many lifetimes in the past. Second and most important is that we remain at the center of the experience at all times, somehow we are able to observe those experiences regardless of the events that created them.

Clearly our memories are not who we are, only the record that tells where we have been and what we have done. Who is it that does the observing? How does it work that this capability remains constant throughout our experience of being conscious?

The Soul contains all of our memories from all our existences both material and immaterial, it includes the yearning and hopes from previous lives and remembers those we loved so deeply that losing them meant that our lives no longer had meaning. Your soul gives you your purpose for living.

SCIET Dynamics explains the soul simply

The Soul is based on the same principles that created atoms at the beginning of the Creation. Point-to-point resonance returns to each point and goes into orbit around the center forming a continuous spherical layer of information. When this happens at the atomic level it creates the Atomic Shell and the same effect is used to store memories around the point of Awareness. This means that your sensory system is interactive with all points that surround you, and that your consciousness utilizes this to process your path forward moment-by-moment. Simply stated, you are behind your eyes utilizing a modeling system to see what is presently around you, to remember what you have seen and experienced and to imagine anything else that you want to visualize. These spherical layers are also reduced to molecular size as they are processed by the mind until they reach their smallest possible size, which is then broadcast throughout the body’s DNA in true Holographic fashion.

At this size the memories are passed to an even smaller dimension where they enter long term memory to form what I have called a Memory Tunnel. The Awareness is able to pass from waking consciousness at the center of your brain to deep ancestral awareness at the center of your Memory Tunnel during any past life. You are able to traverse from one moment to the previous or into deep antiquity by simply imagining that past moment.

This new math allows us to understand how we can be the observer at the center of a spherical field layer of information that exists as a result of the brains energetic field. The layout of the brains parts is consistent with this idea, with the internal reality modeled upside down and backwards, so that the visual field is projected toward the back of the head while the feet are modeled with the top regions the brain. The sky is modeled from point where the spinal cord connects the brain, and is the vanishing point above our heads. All the parts of the body and its sensory system are modeled by the brain using synaptic firing to provoke different spherical memories needed to manage the body.

The new math, the SCIET, reduces all incoming information toward the center until it reaches SOURCE. Therefore all SCIETs are points of Awareness and are, in effect, holes in the fabric of SpaceTime that connect to Source.  All Relationships in SpaceTime are Point-to-Point, meaning that the Soul is in continuous relationship with everything around it. According to its concepts the Soul is a recording of all experiences a being has since it separated from the Awareness that began the Creation.  The SCIET provides a mathematical tool to describe this process using a single cycle integrative effect topology to identify how a single point-to-point fractional reduction becomes a record of that momentary state while alive and also while in the transitionary state between lives. The center of this recording is where the fragment of God exists, and it is this center of Awareness that is charged with evolving, or learning how to operate within the constraints of the accumulated information. So the Soul is a vehicle for Awareness that is descended from the original Awareness that began the creation. In this sense, the Soul is the combination of that Awareness and all of the experiences it has accumulated.  

If you want to imagine what this would look like and how it would be a vehicle during the after life, consider what is written about Orbs that appear when researchers investigate reports of ghosts or visit spiritual sites. The appearance of Orbs of Light is constant in some places and sometimes witnesses report seeing faces or people within them. Additionally, Orbs are reported as UFOs and are always reactive to what people are thinking or saying about them. Recently, a witness from the Secret Space Program has reported being in contact with a race of beings from the Sixth dimension who manifest themselves as Blue Spheres, but can also manifest as humanoid beings in order to meet with him.

The Soul is a point of Awareness surrounded by the energy of its accumulated existences, and appears to us as an orb of light.

 

Dane Arr
April 22. 2019

 

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The Math That Tells Cells What They Are

The Math That Tells Cells What They Are

In 1891, when the German biologist Hans Driesch split two-cell sea urchin embryos in half, he found that each of the separated cells then gave rise to its own complete, albeit smaller, larva. Somehow, the halves “knew” to change their entire developmental program: At that stage, the blueprint for what they would become had apparently not yet been drawn out, at least not in ink.

Since then, scientists have been trying to understand what goes into making this blueprint, and how instructive it is. (Driesch himself, frustrated at his inability to come up with a solution, threw up his hands and left the field entirely.) It’s now known that some form of positional information makes genes variously switch on and off throughout the embryo, giving cells distinct identities based on their location. But the signals carrying that information seem to fluctuate wildly and chaotically — the opposite of what you might expect for an important guiding influence.

“The [embryo] is a noisy environment,” said Robert Brewster, a systems biologist at the University of Massachusetts Medical School. “But somehow it comes together to give you a reproducible, crisp body plan.”

The same precision and reproducibility emerge from a sea of noise again and again in a range of cellular processes. That mounting evidence is leading some biologists to a bold hypothesis: that where information is concerned, cells might often find solutions to life’s challenges that are not just good but optimal — that cells extract as much useful information from their complex surroundings as is theoretically possible. Questions about optimal decoding, according to Aleksandra Walczak, a biophysicist at the École Normale Supérieure in Paris, “are everywhere in biology.”

Biologists haven’t traditionally cast analyses of living systems as optimization problems because the complexity of those systems makes them hard to quantify, and because it can be difficult to discern what would be getting optimized. Moreover, while evolutionary theory suggests that evolving systems can improve over time, nothing guarantees that they should be driven to an optimal level.

Yet when researchers have been able to appropriately determine what cells are doing, many have been surprised to see clear indications of optimization. Hints have turned up in how the brain responds to external stimuli and how microbes respond to chemicals in their environments. Now some of the best evidence has emerged from a new study of fly larva development, reported recently in Cell.

Cells That Understand Statistics

For decades, scientists have been studying fruit fly larvae for clues about how development unfolds. Some details became apparent early on: A cascade of genetic signals establishes a pattern along the larva’s head-to-tail axis. Signaling molecules called morphogens then diffuse through the embryonic tissues, eventually defining the formation of body parts.

Particularly important in the fly are four “gap” genes, which are expressed separately in broad, overlapping domains along the axis. The proteins they make in turn help regulate the expression of “pair-rule” genes, which create an extremely precise, periodic striped pattern along the embryo. The stripes establish the groundwork for the later division of the body into segments.

FIGURE: Gap gene expression compared to "Pair rule" gene expression

Early in the development of fruit flies, four “gap” genes are expressed at different levels along the long axis of the larval body. That pattern lays the foundation for the expression of “pair-rule” genes in periodic bands later, which give rise to specific body segments. The purple stain in the embryo at left shows the expression of one gap protein; the staining in the later larva at right reveals one pair-rule protein.

Development 2002 129:4399-4409

How cells make sense of these diffusion gradients has always been a mystery. The widespread assumption was that after being pointed in roughly the right direction (so to speak) by the protein levels, cells would continuously monitor their changing surroundings and make small corrective adjustments as development proceeded, locking in on their planned identity relatively late. That model harks back to the “developmental landscape” proposed by Conrad Waddington in 1956. He likened the process of a cell homing in on its fate to a ball rolling down a series of ever-steepening valleys and forked paths. Cells had to acquire more and more information to refine their positional knowledge over time — as if zeroing in on where and what they were through “the 20 questions game,” according to Jané Kondev, a physicist at Brandeis University.

Such a system could be accident prone, however: Some cells would inevitably take the wrong paths and be unable to get back on track. In contrast, comparisons of fly embryos revealed that the placement of pair-rule stripes was incredibly precise, to within 1 percent of the embryo’s length — that is, to single-cell accuracy.

That prompted a group at Princeton University, led by the biophysicists Thomas Gregor and William Bialek,to suspect something else: that the cells could instead get all the information they needed to define the positions of pair-rule stripes from the expression levels of the gap genes alone, even though those are not periodic and therefore not an obvious source for such precise instructions.

And that’s just what they found.

Over the course of 12 years, they measured morphogen and gap-gene protein concentrations, cell by cell, from one embryo to the next, to determine how all four gap genes were most likely to be expressed at every position along the head-to-tail axis. From those probability distributions, they built a “dictionary,” or decoder — an explicit map that could spit out a probabilistic estimate of a cell’s position based on its gap-gene protein concentration levels.

Around five years ago, the researchers — including Mariela Petkova, who started the measurement work as an undergraduate at Princeton (and is currently pursuing a doctorate in biophysics at Harvard University), and Gašper Tkačik, now at the Institute of Science and Technology Austria — determined this mapping by assuming it worked like what’s known as an optimal Bayesian decoder (that is, the decoder used Bayes’ rule for inferring the likelihood of an event from prior conditional probabilities). The Bayesian framework allowed them to flip the “unknowns,” the conditions of probability: Their measurements of gap gene expression, given position, could be used to generate a “best guess” of position, given only gap gene expression.

The team found that the fluctuations of the four gap genes could indeed be used to predict the locations of cells with single-cell precision. No less than maximal information about all four would do, however: When the activity of only two or three gap genes was provided, the decoder’s location predictions were not nearly so accurate. Versions of the decoder that used less of the information from all four gap genes — that, for instance, responded only to whether each gene was on or off — made worse predictions, too.

According to Walczak, “No one has ever measured or shown how well reading out the concentration of these molecular gradients … actually pinpoints a specific position along the axis.”

Now they had: Even given the limited number of molecules and underlying noise of the system, the varying concentrations of the gap genes was sufficient to differentiate two neighboring cells in the head-to-tail axis — and the rest of the gene network seemed to be transmitting that information optimally.

“But the question always remained open: Does the biology actually care?” Gregor said. “Or is this just something that we measure?” Could the regulatory regions of DNA that responded to the gap genes really be wired up in such a way that they could decode the positional information those genes contained?

The biophysicists teamed up with the Nobel Prize-winning biologist Eric Wieschaus to test whether the cells were actually making use of the information potentially at their disposal. They created mutant embryos by modifying the gradients of morphogens in the very young fly embryos, which in turn altered the expression patterns of the gap genes and ultimately caused pair-rule stripes to shift, disappear, get duplicated or have fuzzy edges. Even so, the researchers found that their decoder could predict the changes in mutated pair-rule expression with surprising accuracy. “They show that the map is broken in mutants, but in a way that the decoder predicts,” Walczak said.

GRAPHIC: Showing the role of gap genes and pair-rule genes in embryonic development

Lucy Reading-Ikkanda/Quanta Magazine

“You could imagine that if it was getting information from other sources, you couldn’t trick [the cells] like that,” Brewster added. “Your decoder would fail.”

These findings represent “a signpost,” according to Kondev, who was not involved with the study. They suggest that there’s “some physical reality” to the inferred decoder, he said. “Through evolution, these cells have figured out how to implement Bayes’ trick using regulatory DNA.”

How the cells do it remains a mystery. Right now, “the whole thing is kind of wonderful and magical,” said John Reinitz, a systems biologist at the University of Chicago.

Even so, the work provides a new way of thinking about early development, gene regulation and, perhaps, evolution in general.

A Steeper Landscape

The findings provide a fresh perspective on Waddington’s idea of a developmental landscape. According to Gregor, their work indicates that there’s no need for 20 questions or a gradual refinement of knowledge after all. The landscape “is steep from the beginning,” he said. All the information is already there.

“Natural selection [seems to be] pushing the system hard enough so that it … reaches a point where the cells are performing at the limit of what physics allows,” said Manuel Razo-Mejia, a graduate student at the California Institute of Technology.

It’s possible that the high performance in this case is a fluke: Since fruit fly embryos develop very quickly, perhaps in their case “evolution has found this optimal solution because of that pressure to do everything very rapidly,” said James Briscoe, a biologist at the Francis Crick Institute in London who did not participate in this study. To really cement whether this is something more general, then, researchers will have to test the decoder in other species, including those that develop more slowly.

Even so, these results set up intriguing new questions to ask about the often-enigmatic regulatory elements. Scientists don’t have a solid grasp of how regulatory DNA codes for the control of other genes’ activities. The team’s findings suggest that this involves an optimal Bayesian decoder, which allows the regulatory elements to respond to very subtle changes in combined gap gene expression. “We can ask the question, what is it about regulatory DNA that encodes the decoder?” Kondev said.

And “what about it makes it do this optimal decoding?” he added. “That’s a question we could not have asked before this study.”

“That’s really what this work sets up as the next challenge in the field,” Briscoe said. Besides, there may be many ways of implementing such a decoder at the molecular level, meaning that this idea could apply to other systems as well. In fact, hints of it have been uncoveredin the development of the neural tube in vertebrates, the precursor of their central nervous system — which would call for a very different underlying mechanism.

Moreover, if these regulatory regions need to perform an optimal decoding function, that potentially limits how they can evolve — and in turn, how an entire organism can evolve. “We have this one example … which is the life that evolved on this planet,” Kondev said, and because of that, the important constraints on what life can be are unknown. Finding that cells show Bayesian behavior could be a hint that processing information effectively may be “a general principle that makes a bunch of atoms stuck together loosely behave like the thing that we think is life.”

But right now, it is still only a hint. Although it would be “kind of a physicist’s dream,” Gregor said, “we are far from really having proof for this.”

From Wires Under Oceans to Neurons in the Brain

The concept of information optimization is rooted in electrical engineering: Experts originally wanted to understand how best to encode and then decode sound to allow people to talk on the telephone via transoceanic cables. That goal later turned into a broader consideration of how to transmit information optimally through a channel. It wasn’t much of a leap to apply this framework to the brain’s sensory systems and how they measured, encoded and decoded inputs to produce a response.

Now some experts are trying to think about all kinds of “sensory systems” in this way: Razo-Mejia, for instance, has studied how optimally bacteria sense and process chemicals in their environment, and how that might affect their fitness. Meanwhile, Walczak and her colleagues have been asking what a “good decoding strategy” might look like in the adaptive immune system, which has to recognize and respond to a massive repertoire of intruders.

“I don’t think optimization is an aesthetic or philosophical idea. It’s a very concrete idea,” Bialek said. “Optimization principles have time and again pointed to interesting things to measure.” Whether or not they are correct, he considers them productive to think about.

“Of course, the difficulty is that in many other systems, the property being decoded is more difficult than one-dimensional position [along the embryo’s axis],” Walczak said. “The problem is harder to define.”

That’s what made the system Bialek and his colleagues studied so tantalizing. “There aren’t many examples in biology where a high-level idea, like information in this case, leads to a mathematical formula” that is then testable in experiments on living cells, Kondev said.

It’s this marriage of theory and experiment that excites Bialek. He hopes to see the approach continue to guide work in other contexts. “What’s not clear,” he said, “is whether the observation [of optimization] is a curiosity that arises in a few corners, or whether there’s something general about it.”

If the latter does prove to be the case, “then that’s very striking,” Briscoe said. “The ability for evolution to find these really efficient ways of doing things would be an incredible finding.”

Kondev agreed. “As a physicist, you hope that the phenomenon of life is not just about the specific chemistry and DNA and molecules that make living things on planet Earth — that it’s broader,” he said. “What is that broader thing? I don’t know. But maybe this is lifting a little bit of the veil off that mystery.”

Correction added on March 15: The text was updated to acknowledge the contributions of Mariela Petkova and Gašper Tkačik.

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